Thyroid Hormone Regulation of Gene Expression in the Developing Rat Fetal Cerebral Cortex: Prominent Role of the Ca /Calmodulin-Dependent Protein Kinase IV Pathway
نویسندگان
چکیده
Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM) (M.M.B., P.G.-I., G.M.d.E., J.B.), and Center for Biomedical Research on Rare Diseases (CIBERER) (B.M., C.G.-M., G.M.d.E., J.B.), 28029 Madrid, Spain; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 Japan (D.D.); and Instituto de Neurociencias CSICUniversidad Miguel Hernández (E.A., D.N., P.B.), 03550 Alicante, Spain
منابع مشابه
Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway.
Thyroid hormones influence brain development through regulation of gene expression mediated by nuclear receptors. Nuclear receptor concentration increases rapidly in the human fetus during the second trimester, a period of high sensitivity of the brain to thyroid hormones. In the rat, the equivalent period is the last quarter of pregnancy. However, little is known about thyroid hormone action i...
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متن کاملImplications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.
Thyroid hormones influence brain development through regulation of gene expression. This is especially true for Ca2+-dependent regulation since a major pathway is controlled by the Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) which in turn is induced by the thyroid hormone T3. In addition, CaMKIV is involved in regulation of alternative splicing of a number of protein isoforms, among th...
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